DUOFLIP / XZXONE-S INJECTION 1.5 GM

Brand Name : Duoflip / XZXONE-S

Generic Name : Ceftriaxone with Sulbactam for Injection 1.5 gm

Pack Size : Vial

Dosage Form : Powder for Injection

Strength : Ceftriaxone 1g & Sulbactam 500 mg

Therapeutic indications : Ceftriaxone & Sulbactam for Injection is indicated in infections caused by Ceftriaxone sodiumsensitive pathogens and may be used in the clinical settings in Sepsis, Meningitis, Abdominal Infections (e.g. Peritonitis, infection of the biliary tract), infections of the Bones, Joints, Soft tissue, Skin and of wounds, Renal and Urinary Tract Infections, Respiratory tract Infections, particularly Pneumonia, and Ear, Nose and Throat Infections, and uncomplicated gonorrhea. Ceftriaxone & Sulbactam for Injection may also be used for Peri-operative Prophylaxis of Infections. A single dose given Preoperatively may reduce chances of Postoperative Infection.

Pharmacotherapeutic group : Combinations of Cephalosporin and beta-lactamase inhibitors

ATC code : J01DD63

Pharmacodynamic properties : Ceftriaxone is a beta-lactam antibiotic like the penicillins with bactericidal action. Penicillin-binding proteins (PBPs) are responsible for several steps in the synthesis of the cell wall of bacteria and are found in large quantities (several hundred to several thousand molecules/bacterial cell). Ceftriaxone inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to the specific PBPs located inside the bacterial cell wall. Ceftriaxone interferes with PBP-mediated cell wall synthesis leading to cell lysis, which is mediated by bacterial cell wall autolytic enzymes (autolysins), possibly through interference with an autolysin inhibitor.