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Infallible Pharma | INFASUNATE INJECTION
21131
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INFASUNATE INJECTION

INFASUNATE INJECTION


Brand Name : Infasunate


Generic Name : Artesunate Injection IP


Pack Size : Vial + WFI


Dosage Form : Powder for Injection


Strength : 60 mg & 120 mg


Therapeutic indications : Artesunate Injection administered intravenously or intramuscularly, is indicated for the treatment of severe malaria caused by Plasmodium falciparum, in adults and children.


Pharmacotherapeutic group : Antimalaria


ATC code : P01BE03


Pharmacodynamic properties : The mechanism of action of the artemisinins likely involves cleavage of the internal endoperoxide bridge through reaction with haeme within the infected erythrocyte, thereby generating free radicals which alkylate vital parasite proteins. However, artemisinins have also been reported to inhibit an essential parasite calcium adenosine triphosphatase.
The artemisinins are distinguished from other antimalarials by their ability to kill all erythrocytic stages of the malaria parasite, including the relatively inactive ring stage and late schizonts, as well as the gametocytes responsible for malaria transmission. Artesunate and the artemisinins are the most rapid acting of the antimalarials, and they have also been shown to enhance splenic clearance of infected erythrocytes by reducing cytoadherence.

Date

February 18, 2022

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