Brand Name : Inflaclav 1.2
Generic Name : Amoxycillin & Potassium Clavulanate Injection IP 1.2 gm
Pack Size : Vial
Dosage Form : Powder for Injection
Strength : Amoxycillin 1 gm + Clavulanic Acid 0.2 gm
Therapeutic indications : Inflaclav is indicated for the treatment of the following infections in adults and children:
• Severe infections of the ear, nose and throat (such as mastoiditis, peritonsillar infections, epiglottitis, and sinusitis when accompanied by severe systemic signs and symptoms)
• Acute exacerbations of chronic bronchitis (adequately diagnosed)
• Community acquired pneumonia
• Skin and soft tissue infections in particular cellulitis, animal bites, severe dental abscess with spreading cellulitis
• Bone and joint infections, in particular osteomyelitis
• Intra-abdominal infections
• Female genital infections.
Prophylaxis against infections associated with major surgical procedures in adults, such as those involving the:
• Gastrointestinal tract
• Pelvic cavity
• Head and neck
• Biliary tract surgery.
Consideration should be given to official guidance on the appropriate use of antibacterial agents.
Pharmacotherapeutic group : Combinations of penicillins, incl. beta-lactamase inhibitors
ATC code : J01CR02
Pharmacodynamic properties : Amoxicillin is a semisynthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often referred to as penicillin-binding proteins, PBPs) in the biosynthetic pathway of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to weakening of the cell wall, which is usually followed by cell lysis and death.
Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes.
Clavulanic acid is a beta-lactam structurally related to penicillins. It inactivates some beta-lactamase enzymes thereby preventing inactivation of amoxicillin. Clavulanic acid alone does not exert a clinically useful antibacterial effect.
February 18, 2022