XZXONE INJECTION

Brand Name : XZXONE

Generic Name : Ceftriaxone Injection IP 1gm

Pack Size : Vial

Dosage Form : Powder for Injection

Strength : 1 gm

Therapeutic indications : Ceftriaxone is indicated in the treatment of the following infections in adults and children including term neonates (from birth):
Bacterial Meningitis
Community acquired pneumonia
Hospital acquired pneumonia
Acute otitis media
Intra-abdominal infections
Complicated urinary tract infections (including pyelonephritis)
Infections of bones and joints
Complicated skin and soft tissue infections
Gonorrhoea
Syphilis
Bacterial endocarditis
Ceftriaxone may be used:
For treatment of acute exacerbations of chronic obstructive pulmonary disease in adults
For treatment of disseminated Lyme borreliosis (early (stage II) and late (stage III)) in adults and children including neonates from 15 days of age.
For Pre-operative prophylaxis of surgical site infections
In the management of neutropenic patients with fever that is suspected to be due to a bacterial infection.
In the treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above
Ceftriaxone should be co-administered with other antibacterial agents whenever the possible range of causative bacteria would not fall within its spectrum.
Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Pharmacotherapeutic group : Antibacterials for systemic use, Third-generation cephalosporins

ATC code : J01DD04

Pharmacodynamic properties : Ceftriaxone inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.